Process for preparing intermediates for antiatherosclerotic comp

Details Process for preparing intermediates for antiatherosclerotic comp Process for preparing intermediates for antiatherosclerotic comp

1982-05-17

1984-02-28

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549387, 549486, C07D30779

Patent

active

044342969

ABSTRACT:
The present specification provides a total synthesis of known intermediates useful in the synthesis of khellin and antiatherosclerotic analogs thereof. 3-Furoic acid is treated with succinic anhydride and diesterified to 3-carboxy-.delta.-oxo-2-furanbutanoic acid bis (alkyl ester). Following amination, cyclization and bis methylation, 6-formyl-4,7-dimethoxy-5-benzofurancarboxcyclic acid alkyl ester is prepared. This compound is then converted to known intermediates in the synthesis of khellin and analogs. Further, the present invention provides numerous novel anti-atherosclerotic 4,9-di-(C.sub.2 -C.sub.4)-alkoxyfurochromones.

REFERENCES:
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patent: 4284569 (1981-08-01), Gammill
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