Preparation of substituted 1-thiazinyl or 1-thiazolyl-2-aminoben

Details Preparation of substituted 1-thiazinyl or 1-thiazolyl-2-aminoben Preparation of substituted 1-thiazinyl or 1-thiazolyl-2-aminoben

1982-04-08

1984-02-28

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 55, 548181, 542454, C07D23530

Patent

active

044342888

ABSTRACT:
This invention concerns a process for preparing 2-amino-1,5(6)-substituted-benzimidazole compounds by reacting a 1-unsubstituted-2-amino-5(6)-substituted-benzimidazole compound with a sulfonyl chloride or a haloalkyl isothiocyanate in the presence of an alkali metal hydroxide or carbonate, water, and a water-miscible nonhydroxylic solvent.

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Wright, Chem. Reviews, 48, 486-487 (1951).
Price, et al., "Some Sulfondamide Derivatives of 2-Aminobenzimidazole," J. Org. Chem. 12, 269-274 (1947).

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