Monoclonal antibodies specific for the human transferrin recepto

Details Monoclonal antibodies specific for the human transferrin recepto Monoclonal antibodies specific for the human transferrin recepto

1981-10-26

1984-02-28

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Lymphokine

260112R, 435 68, 435240, 435172, 436547, 436548, C12N 502, A61K 39395

Patent

active

044341563

ABSTRACT:
Monoclonal antibodies are produced specific for the cell surface transferrin receptor of human cells. Animals are inoculated with purified human transferrin receptor glycoprotein, human hematopoietic cells or fragments thereof, and spleen cells obtained from the animals are fused with myeloma cells to produce hybridomas. The hybridomas are cultured as clones, and antibodies obtained from the individual clones are tested for their specificty for human transferrin receptor. Clones which produce antibodies specific for the receptor and that interfere with or block transferrin binding are selected for further culturing to produce the antibody, and the antibody is obtained from the culture growth medium or from ascitic fluid of an animal bearing a tumor of the hybridoma. Monoclonal antibodies which block transferrin binding are useful in regulating cell growth and for other therapeutic uses.

REFERENCES:
patent: 4332785 (1982-06-01), Allen
patent: 4361550 (1982-11-01), Kung et al.
patent: 4364933 (1982-12-01), Kung et al.
patent: 4364934 (1982-12-01), Kung et al.
patent: 4364935 (1982-12-01), Kung et al.
patent: 4364936 (1982-12-01), Kung et al.
patent: 4364937 (1982-12-01), Kung et al.
Omary, M. B. et al., Nature, vol. 286, pp. 888-891, (8-1980), (B3/25).
Reinherz, E. J. et al., Proc. Natl. Acad. Sci., vol. 77(3), pp. 1588-1592, (3-1980), OKT9.
Haynes, B. F. et al., J. Immunology, vol. 127(1), pp. 347-351, (07-1981).
Sutherland, R. et al., Proc. Natl. Acad. Sci., vol. 78(7), pp. 4515-4519, (07-1981).
Cotner, T. et al., Journal of Experimental Medicine, vol. 157, pp. 461-472, (2-1983), See p. 469.
Trowbridge, I. S. et al., Nature, vol. 294 (1981), pp. 171-173.

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