Nucleic acids and cells for recombinant production of fibroblast

Details Nucleic acids and cells for recombinant production of fibroblast Nucleic acids and cells for recombinant production of fibroblast

1994-03-08

1998-10-06

Fitzgerald, David L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

536 2351, 536 235, 4353201, 435325, 4353523, 43525411, 435 691, C12N 1516, C07K 1450

Patent

active

058174850

ABSTRACT:
Disclosed is a human FGF-10 polypeptide and DNA(RNA) encoding such FGF-10 polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist/inhibitors against such polypeptide. Such polypeptides may be combined with a suitable pharmaceutical carrier or diluent to provide diagnostic, therapeutic and/or prophylactic effects against various diseases. There is also disclosed methods of utilizing antibodies and antagonists against such polypeptide for therapeutic purposes.

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patent: 5155214 (1992-10-01), Baird et al.
Burgess, W.H. and Maciag, T., The Heparin-Binding (Fi8roblast Growth Factor Family of Proteins, Annv. Rev. Biochem., 58:575-606 (1989).
Basilico, C. and Moscatelli, D., The FGF Family of Growth Factors and Oncogenes, Adv. in Cancer Res., 59:115-165 (1992).
Jaye et al. Science 233:541-545 (1986).
Aaronson et al Ann NY Acad Sci 638: 62-77 (1991).
Barinager Sciences 264: 772-774 (1994).
Basilico et al Adv Caancer Res 59: 115-162 (1992).
Adams, M.D. et al. (1993) Gen Bank database record, Acc. No. T09003.
Adams, M.D. et al. (1993) Nature genetics 4: 373-80.

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