Pyrazole derivative

Details Pyrazole derivative Pyrazole derivative

1990-07-31

1993-02-02

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40310, A61K 31415

Patent

active

051838990

ABSTRACT:
Novel pyrazole derivatives of the formula (I): ##STR1## wherein R is an alkyl group and D is an alkoxy group, a hydroxyl group, a halogen atom or an amino group which may be substituted, and salts thereof show strong antagonistic actions to angiotensin II, thus being useful as therapeutics for cardiovascular diseases.

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Bolis et al., J. Med. Chem, 30, 1729-1737, 1987.
Denkewalter et al., Progress in Drug Research, vol. 10, 510-512, (1966).
Haber et al., J. Cardiovascular Pharmacology, 10 (Supp. 7), 554-58, (1987).
Plattner et al., J. Med. Chem., 31, 2277-2288, (1988).
Burger, A., Medicinal Chemistry, Interscience Publishers, Inc., New York, pp. 565-571, 578-581, 600-601 (1960).

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