Process of preparing cardiotonic 3-methyl-4-(4-pyridinyl)benzene

Details Process of preparing cardiotonic 3-methyl-4-(4-pyridinyl)benzene Process of preparing cardiotonic 3-methyl-4-(4-pyridinyl)benzene

1983-04-14

1985-03-19

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21373, C07D21374

Patent

active

045060754

ABSTRACT:
3-Methyl-4-(4-pyridinyl)benzeneamines, useful as cardiotonic agents, are prepared by reaction of pyridine, benzoyl chloride and an appropriate 3-methyl-N,N-di-lower-alkylbenzeneamine in the presence of copper powder and decomposing the reaction mixture with alkali and, if desired, reacting a resulting 3-methyl-4-(4-pyridinyl)N,N-di-lower-alkylbenzeneamine with hydrogen bromide and pyridine to obtain 3-methyl-4-(4-pyridinyl)benzeneamine.

REFERENCES:
Smith, P. A. S. "Open Chain Nitrogen Compounds", (1965), p. 93.
Koenigs et al., Ann., 509, 142-158, (1934).
Forsythe et al., J. Chem. Soc. 2921, (1926).

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