Acid addition products of N-glycidyl compounds

Details Acid addition products of N-glycidyl compounds Acid addition products of N-glycidyl compounds

1984-08-23

1987-04-21

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544302, 544256, 548264, 548337, 548301, 548302, 548308, C07D40306, C07D23302, C07D24912, C07D25306

Patent

active

046598243

ABSTRACT:
A process for the selective production of defined, partial reaction products of polyfunctional N-glycidyl compounds with hydrohalic acids, pseudohydrohalic acids or acids of phosphorus; mono- or di-ring opening products are obtainable as required. The process is carried out at a pH of from about 2 to 10 which is kept constant within a band of at most 2 units on the pH-scale. N,N'-diglycidyl-N"-(halohydroxypropyl)-urazoles and N-glycidyl-N,N"-bis(halohydroxypropyl) urazoles having pharmaceutical utility are produced in good yield.

REFERENCES:
patent: 4377694 (1983-03-01), Giesecke et al.
patent: 4393060 (1983-07-01), Fischer et al.
House, Modern Synthetic Reactions, 2nd Edition, pp. 298-303, (1972).
Fieser et al., vol. 8, Reagents for Organic Synthesis, (1980) pp. 10-11, 164-165, 228-229, 504-505.
Buehler et al., Survey of Organic Synthesis, vol. 2, Wiley & Sons (1977) pp. 258-259.
Angewandte Chemie/80.Jahrg. 1968/No. 20, pp. 851 and 852, V. M. Budnowski.

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