Novel 4H-1,2,4-triazole derivatives

Details Novel 4H-1,2,4-triazole derivatives Novel 4H-1,2,4-triazole derivatives

1984-02-21

1987-04-21

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548262, 514886, C07D24908, A61K 31395, A61K 3141

Patent

active

046597298

ABSTRACT:
Compounds selected from the group consisting of 4H-1,2,4-triazoles of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be in different positions of the benzene ring, R.sub.1, R.sub.3 and R.sub.4 are individually selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, --CF.sub.3, --NO.sub.2, --NH.sub.2 and NH--AlK and ##STR2## R.sub.2 is selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, halogen, --CF.sub.3, --NO.sub.2, --NH.sub.2, --NH--AlK and ##STR3## and AlK, AlK.sub.1 and AlK.sub.2 are alkyl of 1 to 4 carbon atoms or R.sub.1 and R.sub.2 together and/or R.sub.3 and R.sub.4 together are methylenedioxy, R is selected from the group consisting of ethyl, --CH.sub.2 --COOH and CH.sub.2 --COOAlK.sub.3 and AlK.sub.3 is alkyl of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts, with the proviso that R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are not all hydrogen having a remarkable analgesic activity and a novel method for their preparation.

REFERENCES:
Beilstein's Handbuch der Organischen Chemie, vol. 26, Zweites Erganzungswerke, (Vieste Auflage, Berlin, 1954), p. 35.

Affiliated with

Also associated with

Rating

Novel 4H-1,2,4-triazole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel 4H-1,2,4-triazole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel 4H-1,2,4-triazole derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-752215