Drug delivery

Details Drug delivery Drug delivery

1995-06-07

1999-09-21

Stright, Ronald

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

604 96, A61M 3100

Patent

active

059547065

ABSTRACT:
The invention features a catheter and methods for delivering drug to tissue at a desired location of the wall of a body lumen. The catheter is constructed for insertion in a body lumen and has a catheter shaft and an expandable portion mounted on the catheter shaft. The expandable portion is expandable to a controlled pressure to fill the cross-section of the body lumen and press against the wall of the body lumen. In one embodiment, at least a portion of the exterior surface of the expandable portion is defined by a coating of a tenaciously adhered swellable hydrogel polymer. Incorporated in the hydrogel polymer is an aqueous solution of a preselected drug to be delivered to the tissue or plaque. The hydrogel polymer and drug are selected to allow rapid release of a desired dosage of the drug from the hydrogel polymer coating during compression of the hydrogel polymer coating against the wall of the lumen when the expandable portion is expanded. In other embodiments the polymer is released from the expandable portion in response to pressure, to coat the wall of the body lumen.

REFERENCES:
patent: 3699956 (1972-10-01), Kitrilakis et al.
patent: 4026296 (1977-05-01), Stoy et al.
patent: 4299226 (1981-11-01), Banka
patent: 4330497 (1982-05-01), Agdanowski
patent: 4364392 (1982-12-01), Baran
patent: 4423725 (1984-01-01), Baran et al.
patent: 4448195 (1984-05-01), LeVeen et al.
patent: 4481323 (1984-11-01), Sterling
patent: 4515593 (1985-05-01), Norton
patent: 4589873 (1986-05-01), Schwartz et al.
patent: 4592340 (1986-06-01), Boyles
patent: 4603152 (1986-07-01), Laurin et al.
patent: 4693243 (1987-09-01), Buras
patent: 4714460 (1987-12-01), Calderon
patent: 4732930 (1988-03-01), Tanaka et al.
patent: 4769013 (1988-09-01), Lorenz et al.
patent: 4784647 (1988-11-01), Gross
patent: 4820270 (1989-04-01), Hardcastle et al.
patent: 4832688 (1989-05-01), Sagae et al.
patent: 4876126 (1989-10-01), Takemura et al.
patent: 4909258 (1990-03-01), Kuntz et al.
patent: 4923450 (1990-05-01), Maeda et al.
patent: 4950256 (1990-08-01), Luther et al.
patent: 4983166 (1991-01-01), Yamawaki
patent: 4993412 (1991-02-01), Murphy-Chutorian
patent: 4994033 (1991-02-01), Shockey et al.
patent: 5021044 (1991-06-01), Sharkawy
patent: 5026607 (1991-06-01), Kiezulas
patent: 5041100 (1991-08-01), Rowland et al.
patent: 5047045 (1991-09-01), Arney et al.
patent: 5049132 (1991-09-01), Shaffer et al.
patent: 5091205 (1992-02-01), Fan
patent: 5102402 (1992-04-01), Dror et al.
patent: 5120322 (1992-06-01), Davis et al.
patent: 5135516 (1992-08-01), Sahatjian et al.
patent: 5163906 (1992-11-01), Ahmadi
patent: 5180366 (1993-01-01), Woods
patent: 5213576 (1993-05-01), Abiuso et al.
patent: 5213580 (1993-05-01), Slepian et al.
patent: 5232444 (1993-08-01), Just et al.
patent: 5234456 (1993-08-01), Silvestrini
patent: 5304121 (1994-04-01), Sahatjian
Chapman et al., "A Bioabsorbable Stent: Initial Experimental Results", Circulation (Supp III) 82:0283 (abstract) (Oct. 1990).
Guyton et al., "Inhibition of Rat Arterial Smooth Muscle Cell Proliferation by Heparin: In Vivo Studies with Anticoagulant and Nonanticoagulant Heparin," Cir. Res. 46:625-634 (May 1980).
Ilmain et al., "Volume Transition in a Gel Driven by Hydrogen Bonding", 1991, Nature, 349:400-401.
Irie et al., "Stimuli-responsive polymers: chemical induced reversible phase separation of an aqueous soution of poly(N-isopropylacrylamide) with pendent crown ether groups", 1993, Polymer, 34(21):4531-35.
Langer, "Drug Delivery," IUPAC Meeting, Montreal, Canada (Jul. 12, 1990).
Mamada et al., "Photoinduced Phase Transition of Gels", 1990, Macromolecules, 23:1517-19.
McMath et al., "Experimental Application of Bioprotective Materials to Injured Arterial Surfaces with Laser Balloon Angioplasty", Circulation (Supp. III) 82:0282 (abstract) (Oct. 1990).
Suzuki et al., "Phase Transition in Polymer Gels Induced by Visible Light", 1990, Nature, 346:345-47.
Tarcha, "Diffusion Controlled Systems: Hydrogels", Polymers for Controlled Drug Delivery, CRC Press, Inc., 1991, Ch. 2, pp. 16-37.
Thompson et al., "Heparin and Growth Control of Vascular Cells," Ann. N.Y. Acad. Sci. 556:255-267 (1989).
Tidd et al., "Comparison of Hydrophilic Polymer-Coated Latex, uncoated Latex and PVC Indwelling Balloon Catheters in the Prevention of Urinary Infection," J.Urol. 48:285-291 (1976).
Tokuhiro et al., "NMR Study of Poly(N-isopropylaacrylamide) Gels near Phase Transition", 1991, Macromolecules, 24:2936-43.
Waller B.F. et al., "Vessel Wall Pathology After Angioplasty", CARDIO, Aug. 1990, p. 57, 70-72, 81.
Waller et al., "Morphologic Observations Late after Coronary Balloon Angioplasty" Mechanisms of Acute Injury and Relationship to Restenosis, Radio. 174:961-967 (Mar. 1990).
Wolinsky H. et al., "Local Introduction of Drugs into the Arterial Wall: A Percutaneous Catheter Technique", Journal of Interventional Cardiology, vol. 2, No. 4, 1989, pp. 219-228.
The Andreas Gruentzig Cardiovascular Center News Letter (Spring 1990).
Supplementary European Search Report, EP 92 90 3283, mailed Sep. 15, 1993.
International Search Report for PCT/US91/09804, mailed Apr. 8, 1992.
International Search Report for PCT/US91/09805, mailed Apr. 8, 1992.
International Search Report for PCT/US94/08394, mailed Dec. 23, 1994.

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