Substituted-2-(pyrimidinylthio)acetamidoximes and acetonitriles

Details Substituted-2-(pyrimidinylthio)acetamidoximes and acetonitriles Substituted-2-(pyrimidinylthio)acetamidoximes and acetonitriles

1975-04-22

1976-04-13

Schenkman, Leonard

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424251, C07D23900

Patent

active

039503399

ABSTRACT:
2-(6-alkyl or phenyl-2-pyrimidinylthio)acetamidoximes, in which the 4-position is substituted with the p-chlorobenzylamino, p-methoxyphenylamino, or 1,3-benzodioxol-5-yl-methylamino group, have antiarrhythmic activity. The compounds are prepared from an appropriately substituted 2-pyrimidinylthio)acetonitrile by reaction with hydroxylamine hydrochloride.

REFERENCES:
patent: 3627891 (1971-12-01), Driscoll
patent: 3814761 (1974-06-01), Santilli et al.
patent: 3817998 (1974-06-01), Anderson et al.
patent: 3859288 (1975-01-01), DeAngelis et al.

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