Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1984-09-07
1987-04-21
Kight, John
Drug, bio-affecting and body treating compositions
Lymphokine
436547, 549220, 549289, 548462, 548465, 548415, 435814, 435 19, 435196, 558193, A61K 3900, C07F 940, C07F 965, C07D20948
Patent
active
046595678
ABSTRACT:
A phosphonamidate or phosphonate analog-ligand having a conformation that substantially corresponds to the conformation of a hydrolytic transition state of an amide or ester ligand is used to produce antibodies of predetermined specificity. The antibodies include an epitope that binds to and thereby stabilizes the tetrahedral carbon atom of the amide or ester hydrolysis transition state of the ligand to hydrolyze the ligand at a predetermined site.
REFERENCES:
patent: 3641147 (1972-02-01), Taplias
patent: 3733379 (1973-05-01), Szabo
patent: 3876666 (1975-04-01), Oswald et al.
Lerner Richard A.
Tramontano Alfonso
Draper Garnette D.
Kight John
Scripps Clinic & Research Foundation
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