Molecules with antibody combining sites that bind to hydrolytic

Details Molecules with antibody combining sites that bind to hydrolytic Molecules with antibody combining sites that bind to hydrolytic

1984-09-07

1987-04-21

Kight, John

Drug, bio-affecting and body treating compositions

Lymphokine

436547, 549220, 549289, 548462, 548465, 548415, 435814, 435 19, 435196, 558193, A61K 3900, C07F 940, C07F 965, C07D20948

Patent

active

046595678

ABSTRACT:
A phosphonamidate or phosphonate analog-ligand having a conformation that substantially corresponds to the conformation of a hydrolytic transition state of an amide or ester ligand is used to produce antibodies of predetermined specificity. The antibodies include an epitope that binds to and thereby stabilizes the tetrahedral carbon atom of the amide or ester hydrolysis transition state of the ligand to hydrolyze the ligand at a predetermined site.

REFERENCES:
patent: 3641147 (1972-02-01), Taplias
patent: 3733379 (1973-05-01), Szabo
patent: 3876666 (1975-04-01), Oswald et al.

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