Liposome encapsulation of chelating agents

Details Liposome encapsulation of chelating agents Liposome encapsulation of chelating agents

1973-11-12

1976-01-13

Rosen, Sam

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424365, A61K 31195, A61K 4700

Patent

active

039326578

ABSTRACT:
A method for transferring a chelating agent across a cellular membrane by encapsulating the charged chelating agent within liposomes and carrying the liposome-encapsulated chelating agent to the cellular membrane where the liposomes containing the chelating agent will be taken up by the cells, thereby transferring the chelating agent across the cellular membrane. A chelating agent can be introduced into the interior of a cell of a living organism wherein the liposomes will be decomposed, releasing the chelating agent to the interior of the cell. The released chelating agent will complex intracellularly deposited toxic heavy metals, permitting the more soluble metal complex to transfer across the cellular membrane from the cell and subsequently be removed from the living organism.

REFERENCES:
rahman et al. -- Chem. Abst. Vol. 79, (1973), p. 49585q.
Inchema -- Chem. Abst., Vol. 79, (1973), p. 45830t.

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