Penicillins having a 6.beta.-(.alpha.-etherified oximino) acylam

Details Penicillins having a 6.beta.-(.alpha.-etherified oximino) acylam Penicillins having a 6.beta.-(.alpha.-etherified oximino) acylam

1972-11-07

1976-01-13

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424271, C07D50120

Patent

active

039323854

ABSTRACT:
The invention provides novel antibiotic compounds which are 6.beta.-acylamidopenam-3-carboxylic acids, and non-toxic derivatives thereof, characterized in that the acylamido group has the structure ##EQU1## WHERE R is a hydrogen atom or an organic group and R.sup.a is an etherifying monovalent organic group linked to the oxygen atom through a carbon atom. The compounds may be either syn or anti isomers or may exist as mixtures e.g. containing at least 75 percent of one isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive organisms including penicillinase - producing staphylococci coupled with high activity against strains of the gram-negative organism Haemophilus influenzae. The invention is also concerned with the administration of the compounds.

REFERENCES:
patent: 3546219 (1970-12-01), Long et al.
patent: 3573294 (1971-03-01), Long et al.
Arkis for Kemi 22 pp. 451-467 (1964).
Acta Chemica Scandinavica 19 pp. 281-299 (1965).

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