Ligand compositions and processes for their manufacture and thei

Details Ligand compositions and processes for their manufacture and thei Ligand compositions and processes for their manufacture and thei

1980-06-09

1982-11-09

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 424 12, 548351, G01N 3356, G01N 3360, A61K 4300, C07D21190

Patent

active

043584357

ABSTRACT:
A process for preparing a radioactive ligand by reacting an activated ester of the ligand with a primary amine containing a radioactive isotope.
An essentially pure composition having the formula: ##STR1## where I is I.sup.125 or non-radioactive I.sup.127. A composition comprising a ligand connected by means of an amide linkage to the above essentially pure composition; and
A process for radioimmunoassay using a ligand connected by means of an amide link to an essentially pure composition having the above formula where I is I.sup.125.

REFERENCES:
patent: 4031117 (1977-06-01), Rao
patent: 4069305 (1978-01-01), Polito et al.
patent: 4115539 (1978-09-01), Eisenhardt, Jr. et al.
patent: 4124766 (1978-11-01), Paul et al.
patent: 4197286 (1980-04-01), Rao
patent: 4220598 (1980-09-01), Hixson, Jr. et al.
patent: 4221725 (1980-09-01), Bernstein et al.
patent: 4230621 (1980-10-01), Bernstein et al.
patent: 4277460 (1981-07-01), Kojima et al.

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