Method for protecting against endotoxin-induced shock

Details Method for protecting against endotoxin-induced shock Method for protecting against endotoxin-induced shock

1993-04-07

1995-07-25

Naff, David M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514564, 514561, A61K 31195

Patent

active

054362709

ABSTRACT:
A method for the prophylaxis of shock in a patient induced by endotoxin or bacteremia. The method involves administering a therapeutically effective amount of a chemical composition dissloved in a pharmaceutically compatible solvent to the patient. The preferred chemical composition is arginine.

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Weitzberg et al., Eur. J. Pharmacol. 233(1):85-94 (Mar. 16, 1993) Abstract Medline 93231 208.
Wright et al., Cardiovasc Res 26(1) 1992 Abstract BA93:89410.
Yelich et al., Circ Shock 9(6):589-604 1982 Abstract BA77:92655.
Hutcheson et al., Br J. Pharmacol. 101(4): 815-820 (1990).
Shultz et al., J. Clin Invest. 90:1718-1725 (Nov. 1992).

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