Angiotensin II receptor antagonists

Details Angiotensin II receptor antagonists Angiotensin II receptor antagonists

1994-01-04

1995-07-25

Haley, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514333, 514341, 514365, 514370, 514372, 514374, 514377, 514378, 514380, 514381, 514390, 514391, 514397, A61K 31415, A61K 3141

Patent

active

054362601

ABSTRACT:
Substituted 1-benzylimidazole-5-methylidene hydantoins are disclosed as well as methods of preparing them, pharmaceutical compositions containing them, and methods of using them. Intermediates useful in the preparation of the compounds of the invention are also disclosed and synthetic methods for preparing the novel intermediates. The compounds are useful as antagonists of angiotensin II and thus are useful in the control of hypertension, hyperaldosteronism, congestive heart failure, surgically induced vascular smooth muscle proliferation, and glaucoma.

REFERENCES:
patent: 4335040 (1982-10-01), Furukawa
patent: 4820843 (1989-04-01), Aldrich
patent: 5322950 (1994-06-01), Sircar et al.
patent: 5354766 (1994-10-01), Naka et al.
patent: 5364869 (1994-11-01), De
patent: 5376666 (1994-12-01), Duncia
Meanwell et al., J. Org. Chem., vol. 56, pp. 6897-6904 (1991).

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