Oxazolidine derivatives having anti-diabetic and anti-obesity pr

Details Oxazolidine derivatives having anti-diabetic and anti-obesity pr Oxazolidine derivatives having anti-diabetic and anti-obesity pr

1993-08-30

1995-07-25

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548183, C07D41712, A61K 31425

Patent

active

054362571

ABSTRACT:
Compounds of formula (I): ##STR1## wherein: R is an alkyl group; X is oxygen or sulfur; Y is hydrogen atom or --A--COOH, in which A is an alkylene group; Ar is aryl or substituted aryl group; and pharmaceutically acceptable salts and esters thereof, have use in the treatment or prophylaxis of diabetes, obesity, hyperlipemia, hyperglycemia, complications of diabetes, obesity-related hypertension and osteoporosis.

REFERENCES:
patent: 4572912 (1986-02-01), Yoshioka et al.
patent: 4968707 (1990-11-01), Clark
N. Engl. J. Med., 317, 350-357 (1987).
Diabetes, 37, 1595-1607 (1988).
Diabetes, 39, 477-482 (1990).
Endocrinology, 119, 1786-1792 (1986).
Chem. Pharm. Bull., 30, 3580-3600 (1982).

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