Semi-synthetic immunosuppressive macrolides

Details Semi-synthetic immunosuppressive macrolides Semi-synthetic immunosuppressive macrolides

1991-09-12

1992-09-15

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514183, 540456, A61K 31395, A61K 31695, C07D49816

Patent

active

051478773

ABSTRACT:
Macrolides of the general structural Formula I: ##STR1## have been prepared. These macrolides are antagonists of FK-506-type immunosuppressants and are useful for modifying dosages of FK-506-type immunosuppressants in the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants. Furthermore, the compounds of the present invention may have utility as antidotes for overdoses of FK-506-type immunosuppressants. In addition, these macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants.

REFERENCES:
patent: 3929992 (1975-12-01), Sehgal et al.
patent: 3993749 (1976-11-01), Sehgal et al.
patent: 4650803 (1987-03-01), Stella et al.
patent: 4894366 (1990-01-01), Okuhara et al.
patent: 4916138 (1990-04-01), Ueda et al.
patent: 4929611 (1990-05-01), Okuhara et al.
patent: 4956352 (1990-09-01), Okuhara et al.
patent: 4986382 (1990-09-01), Okuhara et al.
patent: 4987139 (1991-01-01), Chen et al.
patent: 5011844 (1991-04-01), Fehr
patent: 5057608 (1991-10-01), Wyvratt, Jr. et al.
patent: 5064835 (1991-11-01), Bochis et al.
Tanaka et al., J. Am. Chem. Soc., 1987, 109 5031-5033.
Bierer et al., Science, 1990, 250, 556-559.
M. Goulet et al. (I) Tetrahedron Lett., 1991, 36, 4627.
C. Arita, et al., Clin. exp Immunol. 1990, 82, 456-461.
N. Murase et al., Diabetes, 1990, 39, 1584-1586.
J. McCauley et al., Lancet, 1990, 335, 674.
K. Takabayashi, et al., Clin. Immunol. Immunopathol., 1989, 51, 110-117.
M. Sakr, et al. Life Sciences, 1990, 47, 687-691.
D. Askin et al., (I) J. Org. Chem., 1990, 55, 5488-5450.
D. Askin, et al., (II) J. Org. Chem., 2990, 55, 5451-5454.
R. Coleman, et al., Heterocycles, 1989, 28, 157-161.
J. Findlay, et al., Can. J. Chem., 1980, 58, 579-590.
M. Goulet, et al. (II), Tetrahedron Lett., 1990, 31, 4845-4848.
T. Jones et al., J. Am. Chem. Soc., 1989, 111, 1157-1159.
S. Schreiber, Science, 1991, 251, 283-287.

Affiliated with

Also associated with

Rating

Semi-synthetic immunosuppressive macrolides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Semi-synthetic immunosuppressive macrolides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Semi-synthetic immunosuppressive macrolides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-736925