Method for the treatment of malaria

Details Method for the treatment of malaria Method for the treatment of malaria

1975-08-20

1977-06-21

Rosen, Sam

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424263, A61K 3147, A61K 3144

Patent

active

040312208

ABSTRACT:
Pharmaceutical formulations and their preparation, suitable for use in the treatment or prophylaxis of malaria, which comprise a compound of formula (I) ##STR1## where X is hydrogen, an alkali metal, the ammonium radical, or H.(CH.sub.2).sub.n.CO-- where n is 0 to 3, together with a compound of formula (II) ##STR2## where R.sup.3 is C1-C5 alkyl and R.sup.6 and R.sup.7 are the same or different and are each selected from alkyl, alkoxy, aralkoxy and di(C1-C5 alkyl)amino. Formulae (I) and (II) include pharmaceutically and pharmacologically acceptable acid addition salts of the respective compounds. Also provided is a method for the treatment of prophylaxis of malaria in a mammal comprising the administration to the mammal in combination of a compound of formula (I) and a compound of formula (II) as above defined.

REFERENCES:
patent: 3761594 (1973-09-01), Challey
Chemical Abst. vol. 66-75 8th Collective Index (1967-1971) p. 27121s.
Markley et al.-Chem. Abst. vol. 78 (1973) p. 23880m.
Ryley et al.-Annals of Trop. Med. & Parasit. vol. 64 No. 2 (1970) pp. 209-222.
Challey et al.-J. of Parasitology vol. 59 No. 3 (June 1973) pp. 502-504.

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