TGF-B compositions and method

Details TGF-B compositions and method TGF-B compositions and method

1990-05-22

1992-09-15

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 21, A61K 3736

Patent

active

051478544

ABSTRACT:
Transforming growth factor-beta (TGF-beta) is enhanced in its therapeutic activity by utilizing it in combination with a synergistic effective amount of a polyunsaturated fatty acid (PUFA). In a preferred embodiment, type 1 transforming growth factor beta (TGF-.sym.1) exhibits enhanced anti-neoplastic activity when utilized in combination with an n=3 or n=6 polyunsaturated fatty acid. Examples of suitable unsaturated fatty acids include linoleic, alpha-linolenic, arachidonic, gamma-linolenic, dihomogammalinolenic, eicosapentaenoic and docosahexaenoic. Combinations of these agents effectively kill various human carcinoma and melanoma cell lines under defined conditions in vitro at picomolar concentrations of TGF-.beta.1 and at .mu.g/ml concentrations of the polyunsaturated fatty acid, levels where the respective two agents acting alone are ineffective.

REFERENCES:
patent: 4326055 (1982-04-01), Leoliger
patent: 4816442 (1989-03-01), McPherson et al.
patent: 4863902 (1989-09-01), Amagase et al.
JNCI, vol. 77, No. 5, Nov. 1986, Begin et al.
JNCI, vol. 80, No. 3, Apr. 1988, Begin et al.
Chem. Abstracts, vol. 111, 1989, 127695w, Twardzik et al.
Newman, Proc. Natl. Acad. Sci. USA, 87=5543-5547, Jul., 1990.

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