Preparation of 3-hydroxymethyl-7.beta.-aminoadipoyl-7.alpha.-met

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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424246, C07D50102

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active

040310850

ABSTRACT:
This invention relates to the preparation of 3-hydroxymethyl-7.beta.-aminoadipoyl-7.alpha.-methoxy-3-cephem-4-carboxyli c acid from 3-(.alpha.-methoxy-p-sulfo-oxycinnamoyloxymethyl)-7.beta.-aminoadipoyl-7.a lpha.-methoxy-3-cephem-4-carboxylic acid or 3-(.alpha.-methoxy-p-hydroxycinnamoyloxymethyl)-7.beta.-aminoadipoyl-7.alp ha.-methoxy-3-cephem-4-carboxylic acid by treatment at 60.degree. C. and pH 3.5-6.5 for about 1 hour. The starting compounds are isolated as fermentation products produced by various Streptomyces species.

REFERENCES:
patent: 3459746 (1969-08-01), Flynn
patent: 3985742 (1976-10-01), Stapley et al.

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