Monoclonal antibody to polymorphic HLA determinant -B27

Details Monoclonal antibody to polymorphic HLA determinant -B27 Monoclonal antibody to polymorphic HLA determinant -B27

1993-02-05

1994-11-29

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 79, 4351722, 43524027, 435975, 436548, 436821, 5303887, 53038873, 5303913, C07K 1528, C12N 520, G01N 33577

Patent

active

053690109

ABSTRACT:
Novel cell lines, receptors and monoclonal antibodies prepared therefrom that are specific for the human HLA-B27 antigen are provided. The monoclonal antibodies are useful in diagnosis and therapy, particularly with respect to certain rheumatoid disorders.

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Breur and Ivanyi, Histocompatibility Testing 1984, Eds. E. D. Albert et al., Springer-Verlag Press, Berlin, 1984, p. 144, describe qualities of four anti-B27 monospecific typing sera across four human races.
de Waal et al., Histocompatibility Testing 1984, eds. E. D. Albert et al., Springer-Verlag Press, Berlin, 1984, p. 418.
Grumet et al., Hum. Immunol. (1982) 5:61, describe a monoclonal antibody (B27M2) which divides HLA-B27 into two subgroups, and also recognizes B47.
Trapani, Joseph A. et al., Hum. Immunol. (1983) 7:205, Description of a Mouse Monoclonal Anti-HLA-B27 Antibody HLA-ABC-m3.
Antonelli, Paolo et al., Recognition of a unique HLA-B27,7,w22,17,14,w63,w46-Common Epitope by Two Independently Derived Balb/c-Monoclonal Antibodies. Human Immunology 8:296-297 (1983).
Breuning, M. H. et al., Subtypes of HLA -B27 Detected by Cytotoxic T Lymphocytes and Their Role in Self-Recognition. Human Immunology 5:259-268 (1982).
Ellis, Shirley A. et al., Recognition of HLA-B27 and Related Antigen by a Monoclonal Antibody. Human Immunology 5:49-59 (1982).
Rebai, Najet et al., Murine H-2D.sup.d -Reactive Monoclonal Antibodies Recognize Shared Antigenic Determinant(s) on Human HLA-B27 or HLA-B27 Molecules or Both. Immunogenetics 17:357-370 (1983).
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