Ocular insert for the fornix

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

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424428, A61F 900

Patent

active

051476479

ABSTRACT:
A flexible ocular insert device adapted for the controlled sustained release of an ophthalmic drug into the eye, wherein the device includes an elongated cylindrical shaped body having a length of at least 8 mm and with the diameter of its body portion not exceeding 1.9 mm. The sustained release mechanism may be by diffusion or by osmosis or bioerosion. The insert device is advantageously inserted into the upper or lower fornix of the eye so as to be independent of movement of the eye by virtue of the fornix anatomy. In one embodiment of the invention, an insert device having a length of 8 to 25 mm, to suit eyes of different sizes, was employed for use in the lower fornix and a device having a length of 8 to 35 mm was employed for use in the upper fornix. The present insert device is of a size and configuration such that, upon insertion into the upper or lower fornix, the device remains out of the field of vision so as to be well retained in place and imperceptible by a patient over a prolonged period of use. Thus the device can be retained in the upper or lower fornix for 7 to 14 days or longer.

REFERENCES:
patent: 3828777 (1974-08-01), Ness
patent: 3995635 (1976-12-01), Higuchi et al.
patent: 4014335 (1977-03-01), Arnold
patent: 4034758 (1977-07-01), Theeuwes
patent: 4135514 (1979-01-01), Zaffaroni et al.
patent: 4164559 (1979-08-01), Miyata et al.
patent: 4524776 (1985-06-01), Withers et al.

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