Imidazopyridines as angiotensin II antagonists

Details Imidazopyridines as angiotensin II antagonists Imidazopyridines as angiotensin II antagonists

1994-06-06

1995-08-01

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142342, 544127, 546118, A61K 31435, C07D47104

Patent

active

054380634

ABSTRACT:
Novel imidazopyridine derivatives of formula I ##STR1## wherein ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y are as defined herein, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.

REFERENCES:
patent: 4880804 (1989-11-01), Carini et al.
patent: 5223499 (1993-06-01), Greenlee
patent: 5242928 (1993-09-01), Mederski
patent: 5243054 (1993-09-01), Naka et al.
patent: 5332744 (1994-07-01), Chakravarty
Wong, The Journal of Pharmacology and Experimental Therapeutics, vol. 252, No. 2, pp. 719-725 (1990).
Chiu, The Journal of Pharmacology and Experimental Therapeutics, vol. 250, No. 3, pp. 867-874 (1989).

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