Isolated sialylated glycoprotein endosialin, which is expressed

Details Isolated sialylated glycoprotein endosialin, which is expressed Isolated sialylated glycoprotein endosialin, which is expressed

1994-03-30

1995-08-01

Lacey, David L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

514 8, 530350, 530395, 530827, A61K 3900, C07K 1400, C07K 14435

Patent

active

054378656

ABSTRACT:
The invention is an isolated, sialylated glycoprotein, referred to as endosialin, which is expressed by tumor associated vascular endothelium and not normal vascular endothelium. The protein portion of the glycoprotein has a molecular weight of about 95 kilodaltons as determined by SDS-PAGE, and the glycoprotein has a molecular weight of about 165 kilodaltons, also as determined by SDS-PAGE. The oligosaccharides are linked by O-linkages to the protein. The glycoprotein is useful for making antibodies which are in turn used to identify tumor associated vascular endothelium.

REFERENCES:
Rettig et al. PNAS 89: 10832-10836 (1992).
Ruiter et al. J. Invest Dermatol. 93: 255-325 (1989).
Schlingemann et al. Am. J. Pathol. 138: 1335-1347 (1991).
Seed et al. PNAS 84: 3365-3369 (1987).

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