Mass spectrometry from surfaces

Details Mass spectrometry from surfaces Mass spectrometry from surfaces

1999-01-22

2000-03-21

Berman, Jack

Radiant energy

Ionic separation or analysis

With sample supply means

250287, 250282, H01J 4916

Patent

active

060405759

ABSTRACT:
A Time-Of-Flight mass spectrometer is configured with a pulsing region and electronic controls to cause the directing of ions to a surface in the Time-Of-Flight pulsing region. The population of ions resulting from the collecting of said ions on or near said surface is subsequently accelerated into the Time-Of-Flight tube for mass to charge analysis. Ions produced away from said surface located in the pulsing region of a Time-Of-Flight mass spectrometer can be directed to the surface with high or low surface collisional energies. Higher energy ion collisions with the surface can result in Surface Induced Dissociation fragmentation and the resulting ion fragment population can be accelerated into Time-Of-Flight tube where the ions are mass to charge analyzed. Ion mass to charge selection can occur prior to directing ions to the pulsing region surface allowing MS/MS Time-Of-Flight mass analysis with SID. Ion to surface low energy collisions or soft landings resulting in little or no ion fragmentation provide a means for spatially focusing ions on or near the surface prior to accelerating the surface collected ions into the Time-Of-Flight tube. The apparatus and methods described in the invention result in refined control of ion fragmentation energy and improved Time-Of-Flight mass to charge analysis performance.

REFERENCES:
patent: 4851669 (1989-07-01), Aberth
patent: 4978852 (1990-12-01), Williams et al.
patent: 5144127 (1992-09-01), Williams et al.
patent: 5233189 (1993-08-01), Wollnik
patent: 5521382 (1996-05-01), Tanaka et al.
patent: 5569917 (1996-10-01), Buttrill et al.
patent: 5689111 (1997-11-01), Dresch et al.

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