Synthesis of 3-epi vitamin D.sub.3 metabolites and analogs

Details Synthesis of 3-epi vitamin D.sub.3 metabolites and analogs Synthesis of 3-epi vitamin D.sub.3 metabolites and analogs

1999-05-11

2000-03-21

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

568 16, 568 17, C07D30304, C07F 928

Patent

active

060404612

ABSTRACT:
The invention relates to a process for the preparation of vitamin D.sub.3 compounds of formula I. ##STR1## Wherein A is a single or a double bond; B is a single, cis-double, trans double or a triple bond; R.sub.1 and R.sub.2 are independently hydrogen, a lower alkyl, e.g., a C.sub.1 -C.sub.4 alkyl; R.sub.3 and R.sub.4 are independently a lower alkyl, e.g., C.sub.1 -C.sub.4 alkyl, a hydroxyalkyl, and a haloalkyl, e.g., a fluoroalkyl; and X and Y are independently hydrogen or hydroxy in the case when B is a single or a double bond.

REFERENCES:
patent: 5145846 (1992-09-01), Baggiolini et al.
patent: 5428029 (1995-06-01), Doran et al.
patent: 5512554 (1996-04-01), Baggiolini et al.
Kiegel, J. et al., Tetr. Lett. 32: pp. 6058-6060 (1991).
Baggiolini, et al., Journal of Organic Chemistry 51, pp. 3098-3108 (1986).
Steinmeyer et al., Steroids, vol. 57(9), pp. 447-452, 1992.

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