Reagent useful for synthesizing sulfurized oligonucleotide analo

Details Reagent useful for synthesizing sulfurized oligonucleotide analo Reagent useful for synthesizing sulfurized oligonucleotide analo

1998-06-25

2000-03-21

Crane, L. Eric

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2533, 536 2534, 568 22, C07H 2100

Patent

active

060404388

ABSTRACT:
The present invention is directed to a method of synthesizing sulfurized oligonucleotide analogs by reacting an oligonucleotide analog containing a phosphorous(III) linkage with a dithiocarbonic acid diester polysulfide having the formula ##STR1## to produce a sulfurized oligonucleotide analog. The diester polysulfide reagent is useful in solution and solid phase oligonucleotide analog synthesis.

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