5-demethoxyfumagillol derivatives and processes for preparing th

Details 5-demethoxyfumagillol derivatives and processes for preparing th 5-demethoxyfumagillol derivatives and processes for preparing th

1999-05-13

2000-03-21

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549512, 549541, A61K 31335, C07D30132, C07D30308

Patent

active

060403373

ABSTRACT:
Compounds useful as angiogenesis inhibiting agents and processes for their preparation are disclosed. In one embodiment, the compounds of the invention are represented by Formula 1: ##STR1## Also disclosed is a pharmaceutical composition for inhibiting angiogenesis in a mammal, said composition comprising a compound of Formula 1, or a pharmaceutically acceptable salt thereof, as an active ingredient.

REFERENCES:
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Marui,S. and Kishimoto,S., "Chemical Modification of Fumagillin. II. 6-Amino-6-deoxyfumagillol and Its Derivatives," Chem. Pharm. Bull., 40:575-579 (1992).
Marui et al., "Chemical Modification of Fumagillin. I. 6-O-Acyl, 6-O-Sulfonyl, 6-O-Alkyl, and 6-O-(N-Substituted-carbamoyl)fumagillols," Chem. Pharm. Bull., 40:96-101 (1992).
Billington, David C., "Angiogenesis and Its Inhibition: Potential New Therapies In Oncology and Non-Neoplastic Diseases," Drug Design and Discovery, 8:3-35 (1991).
Molander, G.A., and Hahn, G., "Lanthanides in Organic Synthesis. 2. Reduction of .alpha.-Heterosubstituted Ketones," J. Org. Chem., 51:1135-1138 (1986).
Hanson, F. R. and Eble, T. E., "An Antiphage Agent Isolated from Aspergillus Sp.," J. Bact.,58:527-529 (1949).

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