Triazole derivative or salt thereof preparation process thereof,

Details Triazole derivative or salt thereof preparation process thereof, Triazole derivative or salt thereof preparation process thereof,

1999-01-22

2000-03-21

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5482686, A61K 3141, C07D24908

Patent

active

06040325&

ABSTRACT:
Described is a triazole derivative represented by the formula (1): wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an aralkyl group, X.sup.1 and X.sup.2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a halogenoalkyl and n stands for an integer of 0 to 2, or salt thereof; a preparation process of said compound and a pharmaceutical comprising said compound as an effective ingredient.
The compound as described above has high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.

REFERENCES:
Hiroshi Miyauchi, et al., Bioorganic & Medicinal Chemistry Letters, vol. 5, No. 9, pp. 933-936, "Synthesis and Antifungal Activities of Optically Active Isomers of SM-8668", May 4, 1995.
Hiroshi Miyauchi, et al., Bioorganic & Medicinal Chemistry Letters, vol. 5, No. 14, pp. 1479-1482, "Structure-Activity Relationships of Sulfur-Containing Triazole Antifungals", Jul. 20, 1995.

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