Prophylactic or therapeutic drug for renal diseases

Details Prophylactic or therapeutic drug for renal diseases Prophylactic or therapeutic drug for renal diseases

1998-12-08

2000-03-21

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3141

Patent

active

060403241

ABSTRACT:
This invention relates to prophylactic or therapeutic drug for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by general formula (I) ##STR1## wherein R.sup.1 stands for H or an optionally substituted hydrocarbon residue; R.sup.2 stands for an optionally esterified carboxyl group; R.sup.3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring having an optional substituent in addition to R.sup.2 ; Y stands for a bond, --O--, --S(O).sub.m -- (wherein m stands for 0, 1 or 2), or --N(R.sup.4)-- (wherein R.sup.4 stands for H or an optionally substituted alkyl group).

REFERENCES:
patent: 5128256 (1992-07-01), Naka et al.
patent: 5128356 (1992-07-01), Naka et al.
patent: 5162326 (1992-11-01), Naka et al.
patent: 5183899 (1993-02-01), Naka et al.
patent: 5196444 (1993-03-01), Naka et al.
patent: 5250554 (1993-10-01), Naka et al.
patent: 5284661 (1994-02-01), Morimoto et al.
patent: 5719173 (1998-02-01), Nishikawa et al.
patent: 5889036 (1999-03-01), Nishikawa et al.
Kohara et al. "Angiotensin Blockade and the Progression of Renal Damage in the Spontaneously Hypertensive Rat", Hypertension, 21,6:975-979 (1993).
Honma et al. "Renal protective effects of the angiotensin II(Ang II) receptor antagonist CV-11974 . . . ", JASN, 4:513 (1993).
Bohm et al. "The Angiotensin II Antagonist BIBR277 Normalized Blood Pressure and Improves . . . ", The FASEB Jnl., 7,3:A246 (1993).
Wolf, et al., "Glucose-Induced Hypertrophy in Cultured Proximal Tubule Cells: Enhancement by Angiotension II, (All)", The FASEB Jnl., 5,5:A1039 (1991).
Dunn "Prostaglandins, Angiotension II, and Proteinuria", Nephron, 5:30-37 (1990).
Noda et al. "Inhibition of Rabbit Aortic Angiotension II (All) Receptor by CV-11974, A New Nonpeptide All Antagonist", Bio. Pharm., 46,2:311-318 (1993).

Affiliated with

Also associated with

Rating

Prophylactic or therapeutic drug for renal diseases does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Prophylactic or therapeutic drug for renal diseases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prophylactic or therapeutic drug for renal diseases will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-730621