Water-soluble esters of camptothecin compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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A61K 3144

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active

060403136

ABSTRACT:
Non-toxic camptothecin prodrugs are prepared by esterifying the 20-position hydroxyl group of camptothecin derivatives.

REFERENCES:
patent: 4031098 (1977-06-01), Sugasawa et al.
patent: 4473692 (1984-09-01), Miyasaka et al.
patent: 4545880 (1985-10-01), Miyasaka et al.
patent: 4604463 (1986-08-01), Miyasaka et al.
patent: 4914205 (1990-04-01), Sawada et al.
patent: 4943579 (1990-07-01), Vishnuvajjala et al.
patent: 5004758 (1991-04-01), Boehm et al.
patent: 5122526 (1992-06-01), Wall et al.
patent: 5122606 (1992-06-01), Wani et al.
patent: 5180722 (1993-01-01), Wall et al.
patent: 5225404 (1993-07-01), Giovannella et al.
patent: 5227380 (1993-07-01), Wall et al.
patent: 5244903 (1993-09-01), Wall et al.
patent: 5342947 (1994-08-01), Lackey et al.
patent: 5352789 (1994-10-01), Hinz
patent: 5401747 (1995-03-01), Wall et al.
patent: 5559235 (1996-09-01), Luzzio
patent: 5889017 (1999-03-01), Giovanella et al.
Hertzberg et al, Proc. Annu. Meet. Assoc. Cancer Res., 1989, AN 30:A2485 (Abstract).
Ohno et al, Proc. Annu. Meet. Am. Soc. Clin. Oncol., 1989, AN 8:A1010 (Abstract).
Hertzberg et al, J. Med. Chem., vol. 32, pp. 715-720, 1989 (Abstract).
Danishetsky et al, J. Org. Chem., vol. 39, pp. 3430-3432 (1974).
Gilmour et al, J. Mol. Cell. Biol., vol. 7, pp. 141-148 (1987).
Database WPI, Derwent Publications, Ltd., AN 89-179979/25, Dec. 1, 1987, EP 321 122.
Plattner et al, J. Org. Chem., vol. 39, pp. 303-311 (1974).
Plattner et al, J. Am, Chem. Soc., vol. 94, pp. 8613-8615 (1972).
Ronman et al, J. of Lab. Com. and Radiopharm., vol. XVIII, pp. 319-329 (1979).
Nicholas et al, J. Med. Chem., vol. 33, pp. 972-978 (1990).
Wani et al, J. Med. Chem., vol. 23, pp. 554-560 (1980).
Wall et al, J. Med. Chem., vol. 29, pp. 1553-1555 (1986).
Hsiang et al, Cancer Research, vol. 49, pp. 4385-4389 (1989).
Jaxel et al, Cancer Research, vol. 49, pp. 1465-1469 (1989).
Pommier et al, Proc. Annu. Meet. Am. Assoc. Cancer Res., AN 29:A1080 (1988).
Hsiang et al, Proc. Annu. Meet. Am. Assoc. Cancer Res., AN 30:A2476 (1989).
Hsiang et al, J. Bio. Chem., vol. 260, pp. 14873-14878 (1985).
Wani et al, J. Med. Chem., vol. 30, pp. 1774-1779 (1987).
Wani et al, J. Med. chem., vol. 29, pp. 2358-2363 (1986).
Giovanella et al, Science, vol. 246, pp. 1046-1048 (1989).
Nagata et al, Cancer Treatment Reports, vol. 71, pp. 341-348 (1987).

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