Methods ad compositions of (-) ketoconazole for treating fungal

Details Methods ad compositions of (-) ketoconazole for treating fungal Methods ad compositions of (-) ketoconazole for treating fungal

1999-05-18

2000-03-21

Jarvis, William R. A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

A61K 31495, A61K 3150

Patent

active

060403071

ABSTRACT:
Methods and compositions are disclosed utilizing the optically pure (-) isomer of ketoconazole. This compound is a potent drug for the treatment of local and systemic fungal, yeast, and dermatophyte infections, while avoiding the concomitant liability of adverse effects associated with the racemic mixture of ketoconazole.

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patent: 4358449 (1982-11-01), Heeres et al.
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"In Vitro and In Vivo Effects of the Antimycotic Drug Ketoconazole on Sterol Synthesis" by Hugo Van Den Bossche, Gustaaf Willemsens, Willy Cools, Frans Cornelissen, William F. Lauwers, and Jan M. Van Cutsem; Antimicrobial Agents and Chemotherapy, vol. 17 Jun. (1980), pp. 922-928.
"Molecular Basis for the Antimycotic and Antibacterial Activity of N-Substituted Imidazoles and Triazoles: the Inhibition of Isoprenoid Biosynthesis", Vanden Bossche et al. Pestic. Sci 15 , 188-198 (1984).

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