Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1975-08-12
1977-01-18
Roberts, Elbert L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2603971, A61K 3156
Patent
active
040040046
ABSTRACT:
The present invention relates to a series of new fusidic acid derivatives and salts or easily hydrolysable esters thereof, to the preparation of these compounds and to pharmaceutical compositions containing the compounds. The new compounds have the general formula: ##STR1## in which R.sub.1 and R.sub.2 stand for an alkanoyl, aralkanoyl or aroyl radical and R.sub.2 also can be hydrogen; the dotted line between C-24 and C-25 indicates a double bond or a single bond, and the wavy line at C-3 indicates that OR.sub.1 is either .alpha.-oriented or .beta.-oriented. The compounds of the invention have a remarkable anti-inflammatory effect and cause a pronounced relief on patients suffering from arthritis.
The invention also concerns intermediates which in themselves to some extent have an anti-inflammatory activity.
REFERENCES:
patent: 3867413 (1975-02-01), Daehne et al.
Leo Pharmaceutical Products Ltd. A/S
Roberts Elbert L.
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