Heterocyclic compounds

Details Heterocyclic compounds Heterocyclic compounds

1992-06-25

1994-01-25

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546113, 546122, 546123, 546118, 546153, 546167, 546176, 546156, 546180, 546269, A61K 31435, C07D40506

Patent

active

052816133

ABSTRACT:
The invention concerns pharmaceutically useful compounds of the formula I, in which Q, X, G.sup.1, Z and Ra have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.

REFERENCES:
patent: 4920131 (1990-04-01), Huang et al.
patent: 5028615 (1991-06-01), Huang et al.
patent: 5126344 (1992-06-01), Roberts et al.
patent: 5130318 (1992-07-01), Roberts et al.
G. R. Proctor, et al., "Azabenzocycloheptenones. Part XIV. Cyclisation of Amino-acid Derivatives to Tetrahydro-1-benzazepin-5-ones and Tetrahydroquiolin-4-ones" J. Chem. Soc., Perkin Trans. I (1972), 1803-8.
R. D. Youssefyeh, et al. (principal author Huang) J. Med. Chem. (1990), 33, 1186-1194; Chem. Abstr. (1990), 112, 17, abstract 131,890u.
F-C. Huang J. Med. Chem. (1990), 33, 1194-1200.

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