Radioimmunoassay for hepatitis B antigen

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure

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23230B, A61K 4300

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active

040383784

ABSTRACT:
The presence of hepatitis B antigen in serum or plasma can be detected by this technique. Commercially available imitation or cultured pearls coated with antibody to hepatitis B antigen are first reacted with the sample and subsequently reacted with radioactively labeled antibody to hepatitis B antigen. Hepatitis B antigen present in the sample forms a complex consisting of non-radioactive antibody-antigen-and radioactive antibody. The radioactivity emanating from these complexes on pearls is measured. This is indicative of the extent of binding of radioactive antibody and thereby indicating the presence or absence of hepatitis B antigen in an unknown sample.

REFERENCES:
patent: 3794467 (1974-02-01), Adams et al.
patent: 3896218 (1975-07-01), Charm et al.
Catt et al., Nature, vol. 213, No. 5078, pp. 825-827, (Feb. 25, 1967).

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