Formulation of oxypurinol and/or its alkali and alkaline earth s

Details Formulation of oxypurinol and/or its alkali and alkaline earth s Formulation of oxypurinol and/or its alkali and alkaline earth s

1993-03-25

1994-11-29

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

514257, A61K 914

Patent

active

053688643

ABSTRACT:
Formulations of oxypurinol and/or its alkali or alkaline earth salts in non-crystalline form, containing the active substance in the form of a solids dispersion with pharmacologically harmless adjuvants. They have more rapid and higher solubility than oxypurinol and/or its alkali or alkaline earth salts. They can be used for the preparation of drugs having high bioavailability of the active substance oxypurinol.

REFERENCES:
patent: 4978668 (1990-12-01), Babbs
patent: 5021242 (1991-06-01), Romer
Chemical Abstracts, vol. 83, No. 2, 14 Jul. 1975 (Columbus, Ohio, US), J. H. Collett et al.; "Effects of polyvinylpyrrolidone on the solubility and dissolution rate of allopurinol", see p. 340, abstract 15544t, & J. Pharm. Pharmacol. 1974, 26, Suppl., 84P-85P.
Journal of Pharmaceutical Sciences, vol. 60, No. 9, Sep. 1971, Win Loung Chiou et al.: "Pharmaceutical applications of solid dispersion systems", pp. 1281-1302.

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