Therapeutic heterocycles

Details Therapeutic heterocycles Therapeutic heterocycles

1995-10-24

1998-01-20

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514252, 514262, 514291, 514297, 514316, 514318, 514320, 514322, 514323, 514326, 514331, 544310, 544405, 546 90, 546102, 546188, 546189, 546194, 546196, 546199, 546200, 546201, 546207, 546208, 546210, 546211, 546213, 546214, 546217, 546234, A61K 31445, C07D21152

Patent

active

057101698

ABSTRACT:
Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, Q.sup.4, and Q.sup.5 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of SP and NKA are useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.

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A. Graham et al., "Isolation and Characterization of the Human Lung NK-2 Receptor Gene Using Rapid Amplification of cDNA Ends", Biochemical and Biophysical Research Communications, (1991), vol. 177, No. 1, 0-16.
X. Emonds-Alt et al., "Pharmacological Profile and Chemical Synthesis of SR 48968, a Non-Peptide Antagonist of the Neurokinin A (NK2) Receptor", Biorganic & Medicinal Chemistry Letters, (1993), vol. 3, No. 5, 925-930.
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