Polynucleotides that encode the calcitonin gene-related peptide

Details Polynucleotides that encode the calcitonin gene-related peptide Polynucleotides that encode the calcitonin gene-related peptide

1996-07-23

1998-01-20

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

536 231, 536 235, 435325, 4352523, 4353201, C12N 1512, C12N 1563, C12N 1585, C12N 121

Patent

active

057100241

ABSTRACT:
Human CGRP-RCF polypeptides and DNA (RNA) encoding such CGRP-RCF and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such CGRP-RCF for the treatment of diabetes, migrane, pain and inflammation, Parkinson's disease, acute heart failure, hypotension, urinary retention, osteoporosis, hypertension, angina pectoris, myocardial infarction, ulcers, asthma, allergies, psychosis, depression, vomiting, benign prostatic hypertrophy, Paget's disease, obesity, cancer, gigantism and the like. Antagonists against such CGRP-RCF and their use as a therapeutic to treat diabetes, migrane, pain and inflammation, Parkinson's disease, acute heart failure, hypotension, urinary retention, osteoporosis, hypertension, angina pectoris, myocardial infarction, ulcers, asthma, allergies, psychosis, depression, vomiting, benign prostatic hypertrophy, Paget's disease, obesity, cancer, gigantism and the like are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the CGRP-RCF and for detecting altered levels of the polypeptide in a host.

REFERENCES:
Aiyar, N., Rand, K., Elshourbagy, N.A., Zeng, Z., Adamou, J.E., Bergsma, D.J., and Li, Y., "A cDNA Encoding the Calcitonin Gene-related Peptide Type 1 Receptor", Journal of Biological Chemistry, 1996, 271:11325-11329.
Flehmann, B., Muff, R., Hunziker, W., Fischer, J.A. and Born, W., "A Human Orphan Calcitonin Receptor-Like Structure", Biochemical and Biophysical Research Communications, 1995, 206:341-347.
Kroll, B., et al., "Functional expression of a human C5a receptor clone in Xenopus oocytes requires additional RNA", Federation of European Biochemical Societies, 1991, 291:208-210.
Luebke, A.E., Dahl, G.P., Roos, B.A., and Dickerson, I.M., "Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay", Proc. Natl. Acad. Sci. USA, 1996, 93:3455-3460.
Murphy, P.M. and McDermott, D., "Functional Expression of the Human Formyl Peptide Receptor in Xenopus Oocytes Requires a Complementary Human Factor", Journal of Biological Chemistry, 1991, 266:12560-12567.
Schultz, P., Stannek, P., Bischoff, S.C., Dahinden, C.A. and Gierschik, P., "Functional Reconstitution of a Receptor-Activated Signal Transduction Pathway in Xenopus Laevis Oocytes Using the Cloned Human C5a Receptor", Cellular Signalling, 1992, 4:153-161.
Uezono, Y., et al., "Receptors that Couple to 2 Classes of G Proteins Increase cAMP and Activate CFTR Expresed in Xenopus Oocytes", Receptors and Channels, 1993, 1:233-241.
Rudinger, In "Peptide Hormones" (Jun. 1976) ed. J.A. Parsons, University Park Press, Baltimore, pp. 1-7.

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