Method for disinfecting red blood cells

Details Method for disinfecting red blood cells Method for disinfecting red blood cells

1995-07-25

1998-01-20

Richter, Johann

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

A01N 102

Patent

active

057099928

ABSTRACT:
A process to disinfect units of red blood cells by adding an oxidizing agent, for instance ozone generating compounds, in solution to a unit of RBC's (RBC's) or compounds generating ClO.sub.2, the RBC reducing enzymes such as cytochrome b.sub.5 reductase will prevent or reverse oxidative changes, however, the viruses or other microorganisms do not have such enzymes. By adding RBC reducing enzymes to the RBC's before sterilization, the RBC's are further protected from the oxidizing sterilizing solution. The RBC's can be put in storage medium containing a reducing agent. The oxidizing agent may be generated from activated ceramic particles which will generate O.sub.3 (ozone) in solution. This is a convenient and economic method of RBC sterilization. The activated ceramic particles generating O.sub.3 in solution may also be added to units of whole blood.

REFERENCES:
patent: 5019402 (1991-05-01), Kross et al.
patent: 5185371 (1993-02-01), Rubinstein
patent: 5281392 (1994-01-01), Rubinstein

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