Prostaglandins C.sub.2

Details Prostaglandins C.sub.2 Prostaglandins C.sub.2

1976-03-01

1978-04-04

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

195 30, 2604109R, 260413, 260514D, 424305, 424317, C07C17700, C11C 100

Patent

active

040827895

ABSTRACT:
This invention is a group of prostaglandin-like compounds of the formula: ##STR1## wherein m is 0, 1, 2, or 3 and n is 2, 3, 4, or 5, wherein X and Y are --CH.sub.2 CH.sub.2 -- or X is cis--CH.dbd.CH-- and Y is --CH.sub.2 CH.sub.2 -- or cis--CH.dbd.CH--, and wherein R.sub.1 is hydrogen, alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, or phenyl substituted with one, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive, and the pharmacologically acceptable salts thereof when R.sub.1 is hydrogen. These compounds are useful as vasodepressors and antisecretory agents, and in managing cases of renal disfunction.

REFERENCES:
patent: 3816393 (1974-06-01), Hayashi et al.
March, Advanced Organic Chemistry, p. 739 (1968).
N.Y. Academy of Science, 180, 73 (1971).

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