Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1996-01-26
1998-01-20
Rollins, John W.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
514844, 514888, 514909, A61K 3578
Patent
active
057098646
DESCRIPTION:
BRIEF SUMMARY
The present invention relates essentially to the use of an extract of Tephrosia, in particular Tephrosia purpurea for preparing a pharmaceutical composition, in particular a dermatological composition, or as a cosmetic agent, and also to a method of cosmetic treatment constituting an application thereof.
Plants of the genus Tephrosia are subtropical plants widely distributed, in particular in India and in Sri Lanka.
A species of the genus Tephrosia that is particularly preferred in the context of the invention is the plant of the species Tephrosia purpurea. It is a perennial plant having a height of 30 cm to 100 cm, giving 4 to 6 seeds per pod, and having red flowers. The species Tephrosia purpurea is particularly known in India and it is known essentially in Ayurvedic medicine, i.e. in traditional Indian medicine. Various parts have been used to treat a variety of diseases: bronchial, liver, and kidney diseases, and blood purification (see article by Pandey in Quart. J. Crude Drug Res. 13 (1975), pp. 65-68). Seeds of Tephrosia purpurea have also been used for hypoglycemic activity (see article by Rahman et al., in Indian J. Med. Res. 81, April 1985, pp. 418-421). In vitro antimicrobial activity of Tephrosia purpurea is also known (see article by Agarwal et al. in Indian J. Physiol. Pharmac., Vol. 31, No. 4, October-December 1987, pp. 284-286) using a root extract in 90% alcohol in a Soxhlet apparatus.
After intensive research on plants of the genus Tephrosia, and in particular of the species Tephrosia purpurea, the present inventors have discovered, unexpectedly, that extracts, and in particular extracts of the seeds, of the plant Tephrosia, in particular Tephrosia purpurea, present powerful stimulation activity for the enzyme adenylate cyclase. It is known that this enzyme transforms ATP into AMPc and pyrophosphate. Because of this activity, extracts of the genus Tephrosia, in particular of the species Tephrosia purpurea, are valuable for an application in cosmetics or in pharmacy, in particular in dermatology, in body-slimming activity, in anti-inflammatory activity, in pigmenting activity by acting on melanocytes, and in anti-aging activity.
Thus, in a first aspect, the present invention covers the use of an extract of a plant of the genus Tephrosia, in particular the species Tephrosia purpurea, as an active substance for preparing a pharmaceutical composition, in particular a dermatological composition, presenting activity in stimulating the enzyme adenylate cyclase, body-slimming activity, anti-inflammatory activity, pigmenting activity, and anti-aging activity, in particular when applied topically, optionally in a medium, vehicle, or excipient that is pharmacologically, and in particular dermatologically, acceptable.
The invention also covers the use of an extract of a plant of the genus Tephrosia, in particular of the species Tephrosia purpurea, as a cosmetic agent for stimulating the enzyme adenylate cyclase, to obtain a body-slimming effect, to obtain a pigmenting effect, or to obtain an anti-aging effect, in particular when applied topically.
In an advantageous embodiment, the above-specified extract is a seed extract of a Tephrosia plant, in particular a seed extract of the species Tephrosia purpurea.
It should be observed that the plant Tephrosia purpurea is also known, in particular according to the Napralert.RTM. database under the following synonymous names: Cracca purpurea, Galeduba lanceaefolia, Galeduba purpurea, Galepa tinctoria, Tephrosia galegoides, Tephrosia indigofera, Tephrosia lobata, and Tephrosia maxima, all of which are naturally covered by the present invention.
In an advantageous embodiment, this seed extract is a hydroalcoholic extract with a C.sub.1 -C.sub.6 alcohol that is linear or cyclic branched. A particularly preferred alcohol is methanol or ethanol. The relative proportions of water and alcohol may range over wide limits. Nevertheless, substantially equal volume proportions are preferred.
In a second aspect, the present invention also covers a method of cosmetic trea
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Holt, John C; Harris, Mary E; Holt, Angela M; Lange, Eva;
Andre Patrice
Darnault Sylvie
Renimel Isabelle
Parfums Christian Dior
Rollins John W.
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