Process for making pyrano- and thiopyranoindole derivatives

Details Process for making pyrano- and thiopyranoindole derivatives Process for making pyrano- and thiopyranoindole derivatives

1976-10-18

1977-11-01

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260268TR, 26029357, 26029358, 26032634, 2603265SA, 26032682, 2603269, 544142, 544143, 544144, 544 80, 544121, 544129, 544130, C07D49104

Patent

active

040565378

ABSTRACT:
Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives having the amino(lower)alkyl radical only at position 9 possess two substituents at position 1 and may be optionally substituted at position 3, 4, 5, 6, 7, and 8. The derivatives having an amino(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7 and 8. The pyrano- and thiopyranoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the preparation and use of these derivatives are also disclosed.

REFERENCES:
patent: 3852285 (1974-12-01), Demerson et al.

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