Sulfur containing alkenylenyl substituted benzoic acids and phen

Details Sulfur containing alkenylenyl substituted benzoic acids and phen Sulfur containing alkenylenyl substituted benzoic acids and phen

1986-01-27

1987-06-23

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514550, 514570, 548252, 548253, 560 18, 560 14, 562432, 260543P, C07D25704, A61K 3141, C07C 6306

Patent

active

046753354

ABSTRACT:
Pharmaceutical compounds are described of the formula ##STR1## in which R.sup.1 is (i) R.sup.4 O(CH.sub.2 CH.sub.2 O).sub.n (CH.sub.2).sub.m --, where R.sup.4 is hydrogen or C.sub.1-5 alkyl, n is 0 or 1 to 5 and m is 1 to 7, or (ii) R.sup.5 --X-- where R.sup.5 is a polar group and X is a C.sub.6-20 alkylene or a C.sub.6-20 alkenylene radical containing from 1 to 3 double bonds, R.sup.2 is a group of the formula A--B-- where A is --COOH or ##STR2## where R.sup.6 is hydrogen or a protecting group, and B is C.sub.1-6 alkylene, and R.sup.3 is --COOH or ##STR3## where R.sup.7 is hydrogen or a protecting group; or a salt or ester thereof.

REFERENCES:
V. Prelog, et al., Helv. Chim. Acta, 27, 1209 (1944), (Chemical Abstracts 40:848(8) supplied as an English Abstract).
G. A. Russell, et al., J. Org. Chem., 31(9), 2854 (1966).
S. Kano, et al., J. C. S. Chem. Comm., 785 (1978).
Eberbach et al., Chem. Ber., 114, 2979 (1981).
Eberbach et al., Tetrahedron Letters, (48), 4640 (1979).
Tamura et al., Synthesis, (10), 693 (1977).

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