Method for producing a biological reagent

Details Method for producing a biological reagent Method for producing a biological reagent

1978-09-18

1980-06-03

Michl, Paul R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C08L 8900

Patent

active

042060940

ABSTRACT:
Polymeric functional microspheres containing metal or metal compounds are formed by addition polymerization of a covalently bondable olefinic monomer such as hydroxyethylmethacrylate in the presence of finely divided metal or metal oxide particles, such as iron, gold, platinum or magnetite, which are embedded in the resulting microspheres. The microspheres can be covalently bonded to chemotherapeutic agents, antibodies, or other proteins providing a means for labeling or separating labeled cells. Labeled cells or microspheres can be concentrated at a specific body location such as in the vicinity of a malignant tumor by applying a magnetic field to the location and then introducing the magnetically attractable microspheres or cells into the circulatory system of the subject. Labeled cells can be separated from a cell mixture by applying a predetermined magnetic field to a tube in which the mixture is flowing. After collection of the labeled cells, the magnetic field is discontinued and the labeled sub-cell population recovered.

REFERENCES:
patent: 3088875 (1963-05-01), Fisk
patent: 3957741 (1976-05-01), Rembaum
patent: 3959080 (1976-05-01), Orth
patent: 3970518 (1976-07-01), Giaever
patent: 4046723 (1977-09-01), Dorman
patent: 4118349 (1978-10-01), Bonacker
patent: 4138383 (1979-02-01), Rembaum

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