Processes and intermediates for preparing cis(+)3-[4,6-dihydroxy

Details Processes and intermediates for preparing cis(+)3-[4,6-dihydroxy Processes and intermediates for preparing cis(+)3-[4,6-dihydroxy

1994-11-30

1996-07-23

Owens, Amelia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D31128

Patent

active

055391281

ABSTRACT:
Processes, and intermediates, for use in preparing the compound of the formula ##STR1## The compounds of formula II are useful in the preparation of cis (+) N-trifluoromethylsulfonyl-3-[4-hydroxy-6-ArO-chroman-3-ylmethyl]-4-methoxy aniline compounds wherein Ar is defined below. The cis (+) N-trifluoromethylsulfonyl-3-[4-hydroxy-6-ArO-chroman-3-ylmethyl]-4-methoxy aniline compounds are useful for inhibiting the production of leukotrienes and/or blocking leukotriene receptors and in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals.

REFERENCES:
patent: 4661596 (1987-04-01), Kreft et al.
patent: 5059609 (1991-10-01), Eggler et al.
Hackh's Chem. Dictionary pp. 398 and 470 (1987).
Hannon, S. J. et al `A new synthesis of N-blocked dihydrouracil and dihydroorotic acid derivatives using lithium tri-sec-butyl borohydride as reducing agent` CA:30689q 1981.

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