DNA encoding Bcl-2-associated proteins

Details DNA encoding Bcl-2-associated proteins DNA encoding Bcl-2-associated proteins

1993-11-12

1996-07-23

Draper, Garnette D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

530350, 435 691, 435 911, 4353201, C07H 2100, C12N 1512, C12N 1563

Patent

active

055390943

ABSTRACT:
The present invention provides nucleotide sequences encoding proteins and fragments thereof that bind to Bcl-2-related proteins. The invention also provides a Bcl-2-associated protein (BAP) such as Bcl-2-associated protein-1 (BAP-1), which binds to Bcl-2. The invention also provides antibodies that specifically bind to a BAP. The invention further provides methods for detecting agents such as drugs that alter the binding of a BAP such as BAP-1 or Raf-related protein with a Bcl-2-related protein and methods for detecting agents that induce dissociation of a bound complex formed by the association of a BAP and a Bcl-2-related protein. The invention further provides methods for modulating the activity of a Bcl-2-related protein in a cell by introducing into the cell a nucleic acid encoding a BAP or by introducing into the cell an antisense nucleotide sequence, which is complementary to a region of a gene encoding a BAP.

REFERENCES:
Olt vai et al. Cell 74:609-619 (Aug. 27, 1993).
Nunez et al. J. of Immunol. 144:3602-3610 (1990).
Gargio et al. Science 258:302-304 (1992).
Bissonmette et al Nature 359: 552-554 (1992).
Fanidi et al. Nature 359: 554-556 (1992).
Vaux et al Science 258: 1955-1957 (1992).
Alnemri et al. Proc Natl Acad Sci USA 89:7295-99 (1992).
Siegel et al. Proc Natl Acad Sci USA 89:7003-07 (1992).
Sentman et al. Cell 67:879-88 (1991).
Strasser et al Cell 67:889-899 (1991).
McDonnell et al Cell 57:79-88 (1989).
Wagner et al Mol & Cell Biol 13(4):2432-2440 (1993).
Fernandez-Sarabia Nature 366: 274-275 (Nov. 18, 1993).
Lee et al. Current Opinion in Cell Biol. 5:286-91 (1993).
Hanada, Motoi et al., "Regulation of Bcl-2 Oncoprotein Levels with Differentiation of Human Neuroblastoma Cells." Cancer Res. 53:4978-4986 (1993).
Tanaka, Shigeki et al., "Structure-Function Analysis of the Bcl-2 Oncoprotein." J. Biol. Chem. 268:10920-10926 (1993).
Hockenberry, D. et al., "Bcl-2 is an Inner Mitochondrial Membrane Protein that Blocks Programmed Cell Death." Nature. 348:334-336 (1990).
Boise, Lawrence H. "bcl-x, a bcl-2-Related Gene that Functions as a Dominant Regulator of Apoptotic Cell Death." Cell. 74:597-608 (1993).
Miyashita, T. and Reed, J. C. "Bcl-2 Oncoprotein Blocks Chemotherapy-Induced Apoptosis in a Human Leukemia Cell Line." Blood. 81:151-157 (1993).
Vaux, D. L. "Toward an Understanding of the Molecular Mechanisms of Physiological Cell Death." Proc. Natl. Acad. Sci. USA. 90:786-789 (1993).
Vaux, D. et al., "Bcl-2 Gene Promotes Haemopoietic Cell Survival and Cooperated with c-myc to Immortalize Pre-B Cells". Nature. 335:440-442 (1988).
Kocache, Malda M. and Pearson, Gary R. "Protein Kinase Activity Associated with a Cell Cycle Regulated, Membrane-Bound Epstein-Barr Virus Induced Early Antigen." Intervirology. 31:1-13 (1990).

Affiliated with

Also associated with

Rating

DNA encoding Bcl-2-associated proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DNA encoding Bcl-2-associated proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA encoding Bcl-2-associated proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-714089