Yeast-derived epidermal growth factor/urogastrone-like products

Details Yeast-derived epidermal growth factor/urogastrone-like products Yeast-derived epidermal growth factor/urogastrone-like products

1993-02-23

1995-03-14

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 4, 530300, 435 711, A61K 3514, A61K 3702, C12P 2104, A11K 3100

Patent

active

053977700

ABSTRACT:
A medicinal composition comprising an Epidermal Growth Factor-like protein derived from yeast, and a carrier which is pharmaceutically acceptable and suitable for the type of administration and treatment for which the composition is to be used. The yeast-derived protein Has a molecular weight of about 4770 daltons and a murine Epidermal Growth Factor (mEGF) activity equivalent to at least 100 nanograms of mEGF by Elisa Assay Titration. The medicinal composition may be applied topically for purposes such as the treatment of external body wounds, or in ophthalmic surgery such as in cataract or corneal surgery, by incorporating a carrier therein which is pharmaceutically acceptable for the particular topical use. The composition may be administered orally for treatment of such ailments as peptic ulcers by incorporating therein a carrier which is pharmaceutically acceptable for oral administration in oral dosage form. Additionally, the present composition may be formulated in a suitable carrier for parenteral injection to promote bone and tendon repair in a warm blooded animal.

REFERENCES:
patent: 4035485 (1977-07-01), Gregory
patent: 4820690 (1989-04-01), Gregory
patent: 5219998 (1993-06-01), Levin

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