Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-02-07
1996-07-23
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549390, A61K 3135, C07D31180
Patent
active
055389937
ABSTRACT:
The invention relates to compounds of the formula ##STR1## having the (3S,4S) configuration and being essentially free of the (3R,4R) enantiomer, in which A--B indicates an optional 1(2) or 6(1) double bond, X is carboxy, carbalkoxy, or carboxamido, linked to the ring directly or through an alkylene linkage, G is halogen, alkyl, or oxy, and Y is alkyl, oxy, or oxyalkylene. The invention further relates to the synthesis of such compounds, and to pharmaceutical compositions and therapeutic methods in which such compounds may be employed.
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patent: 5036014 (1991-07-01), ElSohly et al.
patent: 5144030 (1992-09-01), Wang et al.
Mechoulam et al., Tetrahedron: Asymmetry, vol. 1, No. 5, pp. 315-318 (1990).
Feigenbaum et al., Proc. Natl. Acad. Sci. USA, vol. 86, pp. 9584-9587 (1989).
Schwartz et al., J. Org. Chem., vol. 51, pp. 5463-5465 (1986).
Breuer Aviva
Burstein Sumner H.
Devane William
Mechoulam Raphael
Peabody John
Richter Johann
Yissum Research Development Company
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