Beta-amyloid peptide production inhibitors and methods for their

Details Beta-amyloid peptide production inhibitors and methods for their Beta-amyloid peptide production inhibitors and methods for their

1992-02-05

1996-07-23

Scheiner, Toni R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 721, 435 692, 435183, 436530, 436531, 5303871, G01N 33567, G01N 33544, G01N 33545, C12Q 168

Patent

active

055388450

ABSTRACT:
A method for identifying compounds capable of inhibiting the production of .beta.-amyloid peptide in cells comprises exposing cultured cells in one or more test compounds. The cells are cultured under conditions which produce amyloid precursor protein and which result in intracellular accumulation of an approximately 22 kD polypeptide which includes the entire sequence of the .beta.-amyloid peptide. Test compounds which cause a change in the accumulation of the 22 kD polypeptide are considered likely candidates for use as drugs for treating .beta.-amyloid diseases, such as Alzheimer's disease.

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